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Visar resultat 1 - 5 av 18 uppsatser som matchar ovanstående sökkriterier.

  1. 1. Effects of phosphorylation on the ADP-ribosylation activity of PARP16

    Kandidat-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Virginia Martín Cristóbal; [2023]
    Nyckelord :ADP-ribosylation; Kinases; PARP16; Phosphorylation; UPR biochemistry; Biochemistry; Chemistry;

    Sammanfattning : PARP16/ARTD15 is an intracellular mono-ADP-ribosyltransferase that catalyzes auto- and heteromodification by transfer of a single ADP-ribose moiety. It belongs to the ADP-ribosyltransferase (ART) superfamily. LÄS MER

  3. 2. Generation of a new ADAPT library for stability improvement

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Sumant Yogesh Salphale; [2023]
    Nyckelord :Phage display; CEACAM5; EpCAM; Trop2; ADAPT; ABD; protein engineering; cancer detection; Fag-display; CEACAM5; EpCAM; Trop2; ADAPT; ABD; proteinteknik; cancerdetektion;

    Sammanfattning : Under senare år har målinriktad terapi varit ett växande område inom cancerterapi som en mer målinriktad behandling än kemoterapi. Dessa behandlingar baseras främst på antikroppsbaserade läkemedel som är ganska stora och komplexa, vilket ökar den totala kostnaden för behandlingen. LÄS MER

  4. 3. Domänspecifik kompetens : Vad författargivna nyckelord bidrar med i ämnesindexering av resurser i litteraturvetenskap

    Master-uppsats, Uppsala universitet/Institutionen för ABM

    Författare :Anna Vahlne; [2023]
    Nyckelord :Author-assigned keywords; Topical access; Subject indexing; Literature; Domain analysis; Svenska ämnesord; Controlled vocabulary; Thematic analysis; Författargivna nyckelord; indexering; litteraturvetenskap; domänanalys; Svenska ämnesord; kontrollerad vokabulär; tematisk analys;

    Sammanfattning : The purpose of this Master’s thesis is to contribute to knowledge of what author-assigned keywords add to the indexing of Swedish dissertations in literature. This study had two research questions: 1) What types of keywords do the authors choose? 2) How do the author-assigned keywords compare to the cataloger-assigned subject headings from the controlled vocabulary Svenska Ämnesord (SAO) regarding types of terms, exhaustivity and specificity? Theoretical perspectives for this study come from Domain analysis which is a core paradigm within the research area Knowledge Organization (see e. LÄS MER

  5. 4. All Negative on the Western Front: Analyzing the Sentiment of the Russian News Coverage of Sweden with Generic and Domain-Specific Multinomial Naive Bayes and Support Vector Machines Classifiers

    Kandidat-uppsats, Uppsala universitet/Institutionen för lingvistik och filologi

    Författare :David Michel; [2021]
    Nyckelord :sentiment analysis; news sentiment; text classification; cross-domain sentiment classification; domain specificity; domain-transfer problem; transfer learning; knowledge transfer; support vector machines; SVM; multinomial naive Bayes; Sweden; Aurora 17; Russia; Russian news; RT; Sputnik; cyberwarfare; influence campaign; disinformation; fake news; propaganda;

    Sammanfattning : This thesis explores to what extent Multinomial Naive Bayes (MNB) and Support Vector Machines (SVM) classifiers can be used to determine the polarity of news, specifically the news coverage of Sweden by the Russian state-funded news outlets RT and Sputnik. Three experiments are conducted. LÄS MER

  7. 5. Characterization of novel bispecific ADAPTs selected for cancer-related targets

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Blenda Hedin; [2021]
    Nyckelord :cancer therapy; alternative administration routes; ADAPT; ABD; protein technology; albumin; simultaneous bispecificity; CCL7; CEACAM5; VEGF-A;

    Sammanfattning : Cancer is still one of the most common causes of death world-wide and in parallel there is a need to update the repertoire of therapies that withstand resistance of recurrent cancers. Since the introduction of antibody therapies as anti-cancer pharmaceuticals, recognized as immunotherapy in health care, it has been an increasing field in cancer therapy, as a more targeted treatment compared to chemotherapy. LÄS MER