Sökning: "new drugs"

Visar resultat 1 - 5 av 346 uppsatser innehållade orden new drugs.

  1. 1. EU Police Cooperation : An analysis on the extent of Spanish and Dutch police cooperation in EU organized crime prevention

    Kandidat-uppsats, Försvarshögskolan

    Författare :Erik Lindell; [2024]
    Nyckelord :Police cooperation; Spain; The Netherlands; EU; Crime prevention; Organized crime; Transnational crime; Polis samarbete; Spanien; Nederländerna; EU; Brottsförebyggande; Organiserad brottslighet; Transnationell brottslighet; Gränsöverskridande brottslighet;

    Sammanfattning : This is an analysis that aims to measure the extent of Spanish and Dutch law enforcement cooperation on issues of transnational organized crime prevention. As major transit hubs for the international narcotics market, Spain and the Netherlands are of particular interest to Europe as a whole, but also specifically Swedish policy-makers who have highlighted the narcotics trade as a key issue in domestic criminal activity. LÄS MER

  3. 2. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemi

    Författare :Maryam Dost; [2024]
    Nyckelord :Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Sammanfattning : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. LÄS MER

  4. 3. Combining Cell Painting, Gene Expression and Structure-Activity Data for Mechanism of Action Prediction

    Master-uppsats, Uppsala universitet/Nationellt resurscentrum för biologi och bioteknik

    Författare :Erik Everett Palm; [2023]
    Nyckelord :bioinformatics; deep learning; machine learning; joint model; tabular data; image data;

    Sammanfattning : The rapid progress in high-throughput omics methods and high-resolution morphological profiling, coupled with the significant advances in machine learning (ML) and deep learning (DL), has opened new avenues for tackling the notoriously difficult problem of predicting the Mechanism of Action (MoA) for a drug of clinical interest. Understanding a drug's MoA can enrich our knowledge of its biological activity, shed light on potential side effects, and serve as a predictor of clinical success. LÄS MER

  5. 4. Systematic Multi-Parametric Analysis of Acute Myeloid Leukemia (AML) Flow Cytometry Drug Screens using Flowty

    Master-uppsats, Lunds universitet/Teknisk mikrobiologi

    Författare :Augusta Jensen; [2023]
    Nyckelord :Acute myeloid leukemia; AML; cellular subpopulations; data analysis; precision medicine; Flowty; applied microbiology; Biology and Life Sciences;

    Sammanfattning : Acute myeloid leukemia (AML) is a heterogeneous disease, making it difficult to treat. The standard treatment is intensive chemotherapy and has not changed in 40 years. However, recently new drugs and as less intensive treatment regimens have been approved in the US and in Europe. However. LÄS MER

  7. 5. Vilka läkemedelsframsteg har förbättrat prognosen för HER2-positiv metastaserad bröstcancer? : En litteraturstudie

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Helena Hansson; [2023]
    Nyckelord :HER2; Bröstcancer; Läkemedel;

    Sammanfattning : Breast cancer is one of the deadliest forms of cancers in the world. About 15–30% of all breast cancers are HER2-positive, which involves overexpression of HER2-receptors on the surface of tumor cells. LÄS MER